Adriana Cherskov Twitch (2024)

1. Cerebellar associative sensory learning defects in five mouse ...

  • 9 jul 2015 · Adriana Cherskov. Department of Molecular Biology and Princeton Neuroscience Institute, Princeton University, Princeton, United States ...

  • On a windy day, hearing the sound of wind makes many individuals squint in anticipation in order to protect their eyes. Linking two sensations that arrive within a split second of one another, such as sound and the feeling of wind, is a type of learning that requires the cerebellum, a region found at the base of the brain. When done in a laboratory setting, this particular form of learning has been dubbed eyeblink conditioning. Individuals with autism tend to have difficulties with appropriate matching of different senses. For example, they have trouble identifying a video that goes with a spoken soundtrack. They also do not learn eyeblink conditioning the same way that other individuals do. However, it is not known which circuits in the brain are responsible for their difficulty. Kloth et al. now investigate this issue by asking whether versions of genes that increase the risk of autism in humans also disrupt eyeblink conditioning in mice. They tested five types of mouse model, each with a different genetic mutation that has previously been linked to autism. All five of these mutations cause defects in different cell types of the cerebellum, and all mice have abnormal social and habitual behaviors, similar to autistic people. The tests involved shining a bright light at the mice, which was followed, a split second later, by a puff of air that always causes the mice to blink. After this had occurred dozens of times, the mice started to blink earlier, as soon as the light appe...

2. Outcomes to PhDs Conferred < MD-PhD Program

  • Adriana Cherskov,“Cellular and molecular features of cerebellar evolution in primates” Mentor: Nenad Sestan, MD, PhD; Interdepartmental Neuroscience Program.

  • Adriana Cherskov,“Cellular and molecular features of cerebellar evolution in primates” Mentor: Nenad Sestan, MD, PhD; Interdepartmental Neuroscience Program 

3. [PDF] FOSTERING LEADERSHIP - Sustainability at Princeton

  • • Pilot a single-stream recycling program and compare it with the existing ... and Adriana Cherskov '14. (Photo by Chris Lillja). Pictured from left are ...

4. [PDF] 20 May 2024 - Yale University

  • 20 mei 2024 · Adriana Cherskov. BA, Princeton University; MPhil, University of ... The Role of Microglia in the Developing Rostral Migratory Stream.

5. Cerebellar associative sensory learning defects in five mouse ...

  • 9 jul 2015 · Adriana Cherskov. Department of Molecular Biology and Princeton Neuroscience Institute, Princeton University, Princeton, United States ...

  • Sensory integration difficulties have been reported in autism, but their underlying brain-circuit mechanisms are underexplored. Using five autism-related mouse models, Shank3+/ΔC, Mecp2R308/Y, Cntnap2-/-, L7-Tsc1 (L7/Pcp2Cre::Tsc1flox/+) and patDp(15q11-13)/+, we report specific perturbations in delay eyeblink conditioning, a form of associative sensory learning requiring cerebellar plasticity. By distinguishing perturbations in the probability and characteristics of learned responses, we found that probability was reduced in Cntnap2-/-, patDp(15q11-13)/+, and L7/Pcp2Cre::Tsc1flox/+, all associated with Purkinje-cell/deep-nuclear gene expression, along with Shank3+/ΔC. Amplitudes were smaller in L7/Pcp2Cre::Tsc1flox/+ as well as Shank3+/ΔC and Mecp2R308/Y, which are associated with granule-cell pathway expression. Shank3+/ΔC and Mecp2R308/Y also showed aberrant response timing and reduced Purkinje-cell dendritic spine density. Overall, our observations are potentially accounted for by defects in instructed learning in the olivocerebellar loop and response representation in the granule cell pathway. Our findings indicate that defects in associative temporal binding of sensory events are widespread in autism mouse models.

6. Lhx6 Activity Is Required for the Normal Migration and Specification ...

  • C. Akufo-Addo's present address: Murine Molecular Constructs Laboratory, Center for Comparative Medicine, County Road 98 and Hutchinson Drive, Davis, CA 95616.

  • The cerebral cortex contains two main neuronal cell populations, the excitatory glutamatergic (pyramidal) neurons and the inhibitory interneurons, which synthesize GABA and constitute 20–30% of all cortical neurons. In contrast to the mostly hom*ogeneous population of projection neurons, cortical interneurons are characterized by remarkable morphological, molecular, and functional diversity. Among the markers that have been used to classify cortical interneurons are the calcium-binding proteins parvalbumin and calretinin and the neuropeptide somatostatin, which in rodents identify mostly nonoverlapping interneuron subpopulations. Pyramidal neurons are born during embryogenesis in the ventricular zone of the dorsal telencephalon, whereas cortical interneurons are generated in the subpallium and reach the cortex by tangential migration. On completion of tangential migration, cortical interneurons switch to a radial mode of migration and enter the cortical plate. Although the mechanisms that control the generation of interneuron diversity are currently unknown, it has been proposed that their site of origin in the ventral forebrain determines their specification into defined neurochemical subgroups. Here, we show that Lhx6 , a gene induced in the medial ganglionic eminence and maintained in parvalbumin- and somatostatin-positive interneurons, is required for the specification of these neuronal subtypes in the neocortex and the hippocampus. We also show that Lhx6 activity is requi...

7. [XLS] T120 - NRSA Individ Fellows - R1120.xls - NIH RePORT

  • ... Cherskov, Adriana, 5, F30, NIMH, F30MH123074-03, 1, $52,694, YALE UNIVERSITY, YALE ... Stream, Kendra Leigh, 5, F32, NIDDK, F32DK131695-02, 1, $78,428, UNIVERSITY ...

  • PK ! ¾bäs£ [Content_Types].xml ¢(  ÄUKOã0¾¯Äˆ|]5na…V¨i° öêÆÓƪ_òL¡ý÷;q¡Z¡RˆRÁ%QbÏ÷˜{ÆÓµ³Å$4ÁWbTE¾ÚøE%®¿E¤¼V6x¨ÄPL''?ƛXp´ÇJ4DñBJ¬p ËÁóÊ<$§ˆ?ÓBFU/Õäépx.ëà < ¨Å“ñÌÕÊRñgÍ¿·JfƋâr»¯¥ª„ŠÑšZ•O^¿!„ùÜÔ C½r]bL 46 äl“aÆtDl…Ü˙Àb7ÒW%Gfaؘˆ?Ùú;íÊû®^ân¹Éh(îT¢åØ»\[ùÒr²<Ò559E¥SÆ¿ê>ÀŸ7£Ì¯Ñ‘…´þ2pG§ß¤ƒ¸×AægÿTd˜Œ#m,à±ËŸA?bnT}O|ŠGð?ö!õ )¸¿ÎJCàîRˆØ?ï;ÐØß}Ç`†þí×_ÃYï¦è¯á×Wkà«>7O“ÝÉ_¯î6z?Uý#¢Þn¡utWîm¥Ž”ì=ä2öÉ? ÿÿ PK ! ^¾e ß _rels/.rels ¢(  ¬’MK1†ï‚ÿ!̽;Û*"Òl/EèMdý1™ý`7™¤...

8. [PDF] The Pattern Seekers

  • Bullmore, Bhismadev Chakrabarti, Tony Charman, Emma Chapman, Adriana. Cherskov ... “Segmentation of the speech stream in a non-human primate: Statistical.

9. 渡辺 雅彦(ワタナベ マサヒコ)(医学研究院 生理系部門 解剖学分野)

  • ... stream is well known, but the endocrine hormonal control mechanisms of ... Adriana Cherskov, Taisuke Miyazaki, Masahiko Watanabe, Toru Takumi, Masanobu ...

  • Enhancement of Haloperidol-Induced Catalepsy by GPR143, an L-Dopa Receptor, in Striatal Cholinergic Interneurons.

10. Advanced search - IRAD Research Portfolio

11. [PDF] 2010 Candidates for the Presidential Scholars Program -- April 2010 (PDF)

  • IL - Carol Stream - Alejandro A. Argueta, Benet Academy. IL - Carol ... WA - Redmond - Adriana Cherskov, Unknown High School. WA - Redmond - Erika O ...

12. skills deficit model: Topics by WorldWideScience.org

  • ... Cherskov, Adriana; Miyazaki, Taisuke; Watanabe, Masahiko; Takumi, Toru; Kano ... stream velocity, which is computed based on measured flow rates during the ...

13. Lhx6 Activity Is Required for the Normal Migration and Specification ...

  • 21 mrt 2007 · ... stream that extended well into the hippocampal anlage (Fig. 7D) ... Adriana Cherskov, Mo Yang, Anahita Amiri, Gianfilippo Coppola ...

  • The cerebral cortex contains two main neuronal cell populations, the excitatory glutamatergic (pyramidal) neurons and the inhibitory interneurons, which synthesize GABA and constitute 20–30% of all cortical neurons. In contrast to the mostly hom*ogeneous population of projection neurons, cortical interneurons are characterized by remarkable morphological, molecular, and functional diversity. Among the markers that have been used to classify cortical interneurons are the calcium-binding proteins parvalbumin and calretinin and the neuropeptide somatostatin, which in rodents identify mostly nonoverlapping interneuron subpopulations. Pyramidal neurons are born during embryogenesis in the ventricular zone of the dorsal telencephalon, whereas cortical interneurons are generated in the subpallium and reach the cortex by tangential migration. On completion of tangential migration, cortical interneurons switch to a radial mode of migration and enter the cortical plate. Although the mechanisms that control the generation of interneuron diversity are currently unknown, it has been proposed that their site of origin in the ventral forebrain determines their specification into defined neurochemical subgroups. Here, we show that Lhx6 , a gene induced in the medial ganglionic eminence and maintained in parvalbumin- and somatostatin-positive interneurons, is required for the specification of these neuronal subtypes in the neocortex and the hippocampus. We also show that Lhx6 activity is requi...

14. [PDF] 2013-2014 - Princeton University Art Museum

  • 30 mei 2014 · The need to develop a sustainable stream of operating funds and make the case for future ... Adriana Cherskov. Jin Yun Chow. Andrea Chu. Suhryoung ...

15. Takumi Toru (00222092) - KAKEN — Researchers

  • ... stream to study autonomic nervous and neuroendocrine system. Place of ... Adriana Cherskov, Taisuke Miyazaki, Masahiko Watanabe, Toru Takumi, Masanobu ...

  • Affiliation (Current):神戸大学,医学研究科,教授, Research Field:Biological Sciences,Biological Sciences,Basic / Social brain science,Pathological medical chemistry,Pathological medical chemistry, Keywords:神経科学,遺伝子,自閉症,生理学,脳・神経,行動学,時計遺伝子,脳神経疾患,クローニング,概日リズム, # of Research Projects:70, # of Research Products:591, Ongoing Project:レジリエンスの物質的基盤

16. [PDF] PART 1 - USPTO

  • Cherskov, Michael J. Childress, George Herman. Chizek, Martin S ... Adriana S. Dallas, Tex. 75240. North Canton, Ohio 44720. New York, N.Y. 10016.

17. multi-sensory cognitive learning: Topics by Science.gov

  • Our everyday lives present us with a continuous stream of multi-modal sensory inputs. ... Kloth, Alexander D; Badura, Aleksandra; Li, Amy; Cherskov, Adriana; ...

18. Arro_Corporation__ilnbke-19-35238 ... - PacerMonitor

  • ... Stream, IL 60132-0500 Adriana Perez Advanced Packaging Tech Labs 200 Larkin Drive Unit H Wheeling, IL 60090 Advantage Control Systems 27 Airport Drive ...

19. 渡辺 雅彦(ワタナベ マサヒコ)(医学研究院 生理系部門 解剖学分野)

  • ... stream, and the expression of the essential NR1 subunit of the N-methyl-D ... Simmons, Tahra Eissa, Jin Nakatani, Adriana Cherskov, Taisuke Miyazaki ...

  • Enhancement of Haloperidol-Induced Catalepsy by GPR143, an L-Dopa Receptor, in Striatal Cholinergic Interneurons.

20. mechanisms underlying autism: Topics by WorldWideScience.org

  • ... stream (Global Dot Motion (GDM)), and the other assessing lower-level ... Cherskov, Adriana; Miyazaki, Taisuke; Watanabe, Masahiko; Takumi, Toru; Kano ...

21. ABRAMOVIC, JOHN Basketball-Military-Business

  • They have three children: Adriana, Ivana, and Stephan. Stephanie is also a ... As the bride of Benedikt Cherskov, she traveled to the United States ...

  • ABRAMOVIC, JOHN Basketball-Military-Business

Adriana Cherskov Twitch (2024)

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